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Article

Acrylamide Induces Mitophagy and Alters Macrophage Phenotype via Reactive Oxygen Species Generation.

International journal of molecular sciences - 8 Feb 2021

Hung Chih-Hsing, Lin Yi-Ching, Tsai Yi-Giien, Lin Yu-Chih, Kuo Chia-Hong, Tsai Mei-Lan, Kuo Chao-Hung, Liao Wei-Ting

Abstract excerpt

Acrylamide is a readily exposed toxic organic compound due to its formation in many carbohydrate rich foods that are cooked at high temperatures. Excessive production of reactive oxygen species (ROS), which is an important factor for mitophagy, has been reported to lead to airway inflammation, hyper-responsiveness, and remodeling. Epigenetic regulation is an important modification affecting gene transcription. In...

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Identifiers

PMID: 33567502
DOI: 10.3390/ijms22041683
PMCID: PMC7914752

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