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On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis

27 May 2025

Abstract excerpt

The lack of clinically predictive potency assays for cell products significantly impedes translation of these therapies. Here, we describe a microfluidic on-chip 3D system for rapid evaluation of a subset of patient-derived bone marrow aspirate concentrate (BMAC) samples used in a phase 3 multicenter trial (NCT03818737) evaluating autologous cells for relieving knee osteoarthritis pain. BMAC clinical samples...

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PMID: 40425577
DOI: 10.1038/s41467-025-60158-w

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