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Article

Ex vivo replication of phenotypic functions of osteocytes through biomimetic 3D bone tissue construction.

Bone - 1 Jan 2018

Sun Qiaoling, Choudhary Saba, Mannion Ciaran, Kissin Yair, Zilberberg Jenny, Lee Woo Y

Abstract excerpt

Osteocytes, residing as 3-dimensionally (3D) networked cells in bone, are well known to regulate bone and mineral homeostasis and have been recently implicated to interact with cancer cells to influence the progression of bone metastases. In this study, a bone tissue consisting of 3D-networked primary human osteocytes and MLO-A5 cells was constructed using: (1) the biomimetic close-packed assembly of 20-25μm...

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Source

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Identifiers

PMID: 29066313
DOI: 10.1016/j.bone.2017.10.019
PMCID: PMC5694355

Genes

SOST
DKK1
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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