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Article

Population pharmacokinetics of oxcarbazepine 10-monohydroxy derivative in Chinese adult epileptic patients.

European journal of hospital pharmacy : science and practice - 1 Mar 2023

Yang QiaoWei, Hu Yan, Zhang XuanLing, Zhang XiaoMin, Dai Haibin, Li Xingang

Abstract excerpt

OBJECTIVE: Oxcarbazepine (OXC) is metabolised to active 10-monohydroxy derivative (MHD) after oral administration. Using this fact we aimed to develop an MHD population pharmacokinetic (PPK) model in Chinese adult epileptic patients to facilitate the clinical implementation of model-guided individualised drug therapy. METHODS: We collected blood samples from Chinese adult epileptic patients taking OXC at the...

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Identifiers

PMID: 35787526
DOI: 10.1136/ejhpharm-2022-003357
PMCID: PMC10086726

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