Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy.

doi:10.1016/j.seizure.2017.07.015

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Article

Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy.

Seizure - 1 Oct 2017

Shen Chunhong, Zhang Bijun, Liu Zhirong, Tang Yelei, Zhang Yinxi, Wang Shan, Guo Yi, Ding Yao, Wang Shuang, Ding Meiping

Abstract excerpt

PURPOSE: The aim of the study is to investigate the effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on plasma oxcarbazepine (OXC) concentrations and therapeutic efficacy in Han Chinese patients with epilepsy. METHODS: We recruited 116 Han Chinese patients with epilepsy who were receiving OXC monotherapy. Blood samples were taken and OXC levels were measured. The polymorphisms of ABCB1 rs1045642,...

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Identifiers

PMID: 28837897
DOI: 10.1016/j.seizure.2017.07.015

Genes

ABCB1
ABCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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