Article
A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses.
Hepato-gastroenterology - 1 Jan 2000
Griga Thomas, Wilkens Christian, Wirkus Natascha, Epplen Joerg, Schmiegel Wolff, Klein Wolfram
Abstract excerpt
BACKGROUND/AIMS: Macrophage migration inhibitory factor (MIF) is an important cytokine involved in the regulation of the innate immune system in IBD. Secreted MIF is able to induce the production of pro-inflammatory cytokines and counteracts anti-inflammatory effects of steroids. We evaluated whether the single nucleotide polymorphism (SNP) G/C at position -173 of the MIF gene contributes to the predisposition to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.