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Identification of the TP53-induced glycolysis and apoptosis regulator in various stages of colorectal cancer patients

17 Dec 2015

Abstract excerpt

The TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target gene known to regulate glycolysis by acting as fructose bis-phosphatase (FBPase) and modulate reactive oxygen species. TIGAR expression has been implicated in oncogenesis and progression of several human cancers. However, TIGAR expression is not known in various stages of colorectal cancer (CRC). There is an increase in the colorectal...

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PMID: 26675982
DOI: 10.3892/or.2015.4494

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