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Telomeres and Telomerase in the Control of Stem Cells

20 Sept 2022

Abstract excerpt

Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerative potential of high-turnover organs, causing or contributing to the onset of age-related diseases. In this review,...

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PMID: 36289597
DOI: 10.3390/biomedicines10102335

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