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Telomere and telomerase in stem cells: relevance in ageing and disease

26 Oct 2011

Abstract excerpt

Telomeres, at the end of chromosomes provide genomic stability. During embryonic development, telomerase, a reverse transcriptase elongates the ends of the DNA. In somatic cells, the activity of telomerase decreases after birth leading to shortening of telomere with cell division, which thereby triggers senescence. In embryonic stem cells and germ cells, telomere length is maintained. In adults, the tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22202040
DOI: 10.2741/248

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