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Inhibition of histone methyltransferase G9a aggravates phenotypic severity of hepatic lipotoxicity in non-alcoholic steatohepatitis (NASH).

Biochemical and biophysical research communications - 1 Jan 2025

Rajak Sangam, Shah Arunim, Yadav Abhishek, Shahi Ambuj, Raza Sana, Singh Mable M, Chaturvedi Chandra P, Sinha Rohit A

Abstract excerpt

Lipotoxicity is a key pathological feature in the development of non-alcoholic steatohepatitis (NASH), which is characterized by liver injury, inflammation, and fibrosis. Although lipotoxicity has been shown to induce transcriptomic alterations in liver cells, the specific role of epigenetic regulators in NASH remains elusive. In this study, we demonstrate that pharmacological inhibition of histone...

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PMID: 39693938
DOI: 10.1016/j.bbrc.2024.151171

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