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Article

Protective genetic variants against Alzheimer's disease.

The Lancet. Neurology - 1 Jun 2025

Marino Claudia, Malotaux Vincent, Giudicessi Averi, Aguillon David, Sepulveda-Falla Diego, Lopera Francisco, Quiroz Yakeel T

Abstract excerpt

Genetic studies can offer powerful insights for the development of disease-modifying therapies for Alzheimer's disease. Protective genetic variants that delay the onset of cognitive impairment have been found in people with sporadic Alzheimer's disease and in carriers of mutations that usually cause autosomal-dominant Alzheimer's disease in mid-life. The study of families who carry autosomal dominant mutations...

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Source

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Identifiers

PMID: 40409316
DOI: 10.1016/S1474-4422(25)00116-4
PMCID: PMC12614636

Genes

APOE
RELN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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