Article
Protective mutations associated with APOE in Alzheimer's disease.
Molecular psychiatry - 1 Jul 2026
Ma Yuejia, Li Yanxi, Wu Guangrun, Liu Lulu, Tian Mengjie, Han Xinyu, Chen Xinyi, Xuan Xiuchen, Zheng Tianhu, Gao Xu, Xia Qing, Li Fuyuan, Wang Dayong
Abstract excerpt
Alzheimer' s disease (AD) is a progressive neurodegenerative disorder characterized by a spectrum of cognitive impairments, ranging from mild memory loss to severe cognitive decline and, ultimately, death. The global incidence of AD is projected to increase significantly, with late-onset AD being predominantly sporadic in nature. Over the past three decades, the Apolipoprotein E (APOE) gene has been recognized as...
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