Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of nonfunctional CABS1 causing fertilization failure and male infertility in humans: a case report.

Journal of assisted reproduction and genetics - 1 Jul 2025

Huang Yilian, Wang Yize, Li Lou, Gong Fei, Lin Ge, Dai Jing

Abstract excerpt

PURPOSE: This study aimed to identify new genes associated with total fertilization failure (TFF) by intracytoplasmic sperm injection (ICSI). METHODS: Whole-exome sequencing (WES) was performed on a patient presenting with TFF by ICSI. To assess the spermatozoa's morphology and ultrastructure, hematoxylin and eosin (H&E) staining and transmission electron microscopy (TEM) were employed. Furthermore,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exome Sequencing
Share to Fertilization
Share to Fertilization in Vitro

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Phosphoinositide Phospholipase C

Share to Sperm Injections, Intracytoplasmic

Share to Sperm Motility

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 40407971
DOI: 10.1007/s10815-025-03516-3
PMCID: PMC12356792

Genes

CABS1
ACTL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of nonfunctional CABS1 causing fertilization failure and male infertility in humans: a case report.PMID 40407971Read ↗

Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failureSemantic proximity Read ↗

Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failureSemantic proximity Read ↗

Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure.Semantic proximity Read ↗

ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucidaSemantic proximity Read ↗

Novel ACTL7A variants in males lead to fertilization failure and male infertility.Semantic proximity Read ↗

Three Novel Mutations in TUBB8 Cause Female Infertility Due to Multiple Morphological Abnormalities of the Oocyte and Early Embryo.Semantic proximity Read ↗

SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility.Semantic proximity Read ↗

The identification of novel mutations in PLCZ1 responsible for human fertilization failure and a therapeutic intervention by artificial oocyte activationSemantic proximity Read ↗

Pathogenic homozygous PLCZ1 mutation reduces sperm protein levels with a simulated reduction of PIP2 binding: a case report.Semantic proximity Read ↗

Novel DNAH17 mutations associated with fertilization failures after ICSI.Semantic proximity Read ↗

Lessons learned from the exome sequencing of nine cases of infertility and the way forward.Semantic proximity Read ↗

Novel PLCZ1 mutation caused polyspermy during in vitro fertilization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.