Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel PLCZ1 mutation caused polyspermy during in vitro fertilization.

Asian journal of andrology - 1 Jul 2024

Tong Ke-Ya, Liu Wei-Wei, Sun Li-Wei, Liu Dong-Yun, Xiang Ye-Zhou, Li Chong, Chai Lu-Wei, Chen Ke, Huang Guo-Ning, Li Jing-Yu

Abstract excerpt

Failure of oocyte activation, including polyspermy and defects in pronuclear (PN) formation, triggers early embryonic developmental arrest. Many studies have shown that phospholipase C zeta 1 ( PLCZ1 ) mutations cause failure of PN formation following intracytoplasmic sperm injection (ICSI); however, whether PLCZ1 mutation is associated with polyspermy during in vitro fertilization (IVF) remains unknown....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exome Sequencing
Share to Fertilization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fertilization in Vitro

Share to Mutation, Missense

Share to Oocytes

Share to Phosphoinositide Phospholipase C

Share to Sperm Injections, Intracytoplasmic

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 38445955
DOI: 10.4103/aja202376
PMCID: PMC11280200

Genes

PLCZ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel PLCZ1 mutation caused polyspermy during in vitro fertilization.PMID 38445955Read ↗

The identification of novel mutations in PLCZ1 responsible for human fertilization failure and a therapeutic intervention by artificial oocyte activationSemantic proximity Read ↗

Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization.Semantic proximity Read ↗

Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure.Semantic proximity Read ↗

Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF: not just ICSI failure.Semantic proximity Read ↗

Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI.Semantic proximity Read ↗

Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSISemantic proximity Read ↗

SPERM FACTORS AND EGG ACTIVATION: Fertilization failure after human ICSI and the clinical potential of PLCZ1Semantic proximity Read ↗

Novel homozygous variations in PLCZ1 lead to poor or failed fertilization characterized by abnormal localization patterns of PLCζ in spermSemantic proximity Read ↗

Pathogenic homozygous PLCZ1 mutation reduces sperm protein levels with a simulated reduction of PIP2 binding: a case report.Semantic proximity Read ↗

A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure.Semantic proximity Read ↗

Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failureSemantic proximity Read ↗

Novel mutations in PLCZ1 lead to early embryonic arrest as a male factorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.