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Article

Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure.

Journal of assisted reproduction and genetics - 1 Jan 2023

Peng Yawen, Lin Yuting, Deng Kai, Shen Jiandong, Cui Yugui, Liu Jiayin, Yang Xiaoyu, Diao Feiyang

Abstract excerpt

PURPOSE: To investigate the genetic causes of polyspermy and total fertilization failure (TFF) in two independent male patients suffering from male infertility. METHODS: Immunofluorescence (IF) staining was used to detect the localization of the PLCζ protein in sperm and the maternal pronucleus in the zygote. Genomic DNA samples were extracted from the peripheral blood of patients and their families. The ExAC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36529831
DOI: 10.1007/s10815-022-02670-2
PMCID: PMC9840742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure.PMID 36529831Read ↗

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