Novel DNAH17 mutations associated with fertilization failures after ICSI.

Abstract excerpt

OBJECTIVE: Fertilization is a key event in human reproduction. The male genetic factors associated with total fertilization failure (TFF) are largely unknown. To date, only mutations in PLCZ1 have been reported as male factors that result in human fertilization failure. Here, we report a novel DNAH17 mutation that resulted in male infertility and TFF. METHODS: A male patient with a three-year history of primary...

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