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Article

Parameter Scaling in Population Genetics Simulations may Introduce Unintended Background Selection: Considerations for Scaled Simulation Design.

Genome biology and evolution - 30 May 2025

Ferrari Tessa, Feng Siyuan, Zhang Xinjun, Mooney Jazlyn

Abstract excerpt

Scaling is a common practice in population genetic simulations to increase computational efficiency. However, few studies systematically examine the effects of scaling on diversity estimates and the comparability of scaled results to unscaled simulations and empirical data. We investigate the effects of scaling in two species, modern humans and Drosophila melanogaster. These species have stark differences in...

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PMID: 40405504
DOI: 10.1093/gbe/evaf097
PMCID: PMC12147024

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