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Article

Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes.

PLoS computational biology - 1 May 2016

Kelleher Jerome, Etheridge Alison M, McVean Gilean

Abstract excerpt

A central challenge in the analysis of genetic variation is to provide realistic genome simulation across millions of samples. Present day coalescent simulations do not scale well, or use approximations that fail to capture important long-range linkage properties. Analysing the results of simulations also presents a substantial challenge, as current methods to store genealogies consume a great deal of space, are...

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PMID: 27145223
DOI: 10.1371/journal.pcbi.1004842
PMCID: PMC4856371

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