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Article

ARGON: fast, whole-genome simulation of the discrete time Wright-fisher process.

Bioinformatics (Oxford, England) - 1 Oct 2016

Palamara Pier Francesco

Abstract excerpt

MOTIVATION: Simulation under the coalescent model is ubiquitous in the analysis of genetic data. The rapid growth of real data sets from multiple human populations led to increasing interest in simulating very large sample sizes at whole-chromosome scales. When the sample size is large, the coalescent model becomes an increasingly inaccurate approximation of the discrete time Wright-Fisher model (DTWF)....

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PMID: 27312410
DOI: 10.1093/bioinformatics/btw355
PMCID: PMC6191159

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