Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis B virus genome mutations in precore and basal core promoter regions among HBeAg-negative chronic hepatitis B patients with high viral load in Indonesia.

PloS one - 1 Jan 2026

Wulandari Dewi, Mardian Yan, Sunita, Darmayoga Kadek Aditya, Agustiani Rindha, Khoirunnisa, Ophinni Youdiil

Abstract excerpt

Hepatitis B e antigen (HBeAg) is widely used as a marker for active HBV replication and serves as a surrogate for HBV DNA > 200,000 IU/mL to determine eligibility for tenofovir disoproxil fumarate (TDF) prophylaxis to prevent vertical transmission, according to WHO guidelines. However, some HBeAg-negative patients still harbor high viral loads. Mutations in the precore (PC) and basal core promoter (BCP) regions...

Read the complete abstract on PubMed

Topics

Humans
Hepatitis B virus
Indonesia
Hepatitis B, Chronic
Hepatitis B e Antigens
Viral Load

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Promoter Regions, Genetic

Mutation

Adult

Male

Female

Genome, Viral

Cross-Sectional Studies

DNA, Viral

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 42743256
DOI: 10.1371/journal.pone.0357754
PMCID: PMC13577486

Genes

PC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis B virus genome mutations in precore and basal core promoter regions among HBeAg-negative chronic hepatitis B patients with high viral load in Indonesia.PMID 42743256Read ↗

Clinical Features of Chronic Hepatitis B in Treatment-naive Asian Patients With Positive HBeAg and Coexisting Precore and/or Basal Core Promoter Mutations.Semantic proximity Read ↗

Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients.Semantic proximity Read ↗

Prevalence of basal core promoter and precore mutations in Chinese chronic hepatitis B patients and correlation with serum HBeAG titers.Semantic proximity Read ↗

Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversionSemantic proximity Read ↗

Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.Semantic proximity Read ↗

Molecular characterization of hepatitis B virus basal core promoter and precore region of isolates from chronic hepatitis B patients.Semantic proximity Read ↗

Unraveling the Role of Mutations Outside the Basal Promoter and Precore Regions in the HBeAg-Negative Stage of Chronic Hepatitis B.Semantic proximity Read ↗

Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection.Semantic proximity Read ↗

Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients.Semantic proximity Read ↗

Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia.Semantic proximity Read ↗

Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes.Semantic proximity Read ↗

Evolutionary Insights of Hepatitis B Virus Genotypes and Profiles of Mutations in Surface and Basal Core Promoter/Pre-Core Genes Among HBsAg-Positive Patients in North-Central and Southwestern Nigeria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.