Article

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer

2024-02-28

Abstract excerpt

DNA sequence mutability in tumors with chromosomal instability is conventionally believed to remain uniform, constant, and low, based on the assumption that further mutational accrual in a context of marked aneuploidy is evolutionarily disadvantageous. However, this concept lacks robust experimental verification. We adapted the principles of mutation accumulation experiments, traditionally performed in lower organ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41239abf-d570-5430-80f3-b88a3730bd91
DOI: 10.1101/2024.02.26.582054

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancerDOI 10.1101/2024.02.26.582054Read

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancerSemantic proximity Read

Somatic microsatellite mutations as molecular tumor clocks.Semantic proximity Read

Heterogeneity in Microsatellite Instability in Metastatic Colorectal Cancer: Mechanisms and Clinical ImplicationsSemantic proximity Read

Unexpectedly High Subclonal Mutational Diversity in Human Colorectal Cancer and Its SignificanceSemantic proximity Read

Accumulated Clonal Genetic Alterations in Familial and Sporadic Colorectal Carcinomas with Widespread Instability in Microsatellite SequencesSemantic proximity Read

Update of genetics in colorectal carcinomas: genomic instability and somatic evolution.Semantic proximity Read

Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.Semantic proximity Read

Microsatellite instability. Shifting concepts in tumorigenesis.Semantic proximity Read

Multiple mutations in human cancers.Semantic proximity Read

Extensive subclonal mutational diversity in human colorectal cancer and its significanceSemantic proximity Read

Genetic instability and divergence of clonal populations in colon cancer cells in vitro.Semantic proximity Read

The onset and extent of genomic instability in sporadic colorectal tumor progressionSemantic proximity Read