Article
Using eQTL Mendelian randomization and transcriptomic analysis to identify the relationship between ion channel genes and intracranial aneurysmal subarachnoid hemorrhage.
Medicine - 16 May 2025
Wang Jing, Chen Bowang, Meng Qiang, Qu Feng, Ma Zhen
Abstract excerpt
Aneurysmal subarachnoid hemorrhage (aSAH) is a complex condition associated with high disability and mortality rates, leading to poor clinical outcomes. Previous observational studies have suggested a link between ion channel genes and aSAH, but the causal relationship remains uncertain. This study utilized Mendelian randomization (MR) to explore the causal association between ion channel genes and aSAH,...
Topics
- Humans
- Subarachnoid Hemorrhage
- Mendelian Randomization Analysis
- Ion Channels
- Quantitative Trait Loci
- Gene Expression Profiling
- Intracranial Aneurysm
- Transcriptome
- Genetic Predisposition to Disease