Using eQTL Mendelian randomization and transcriptomic analysis to identify the relationship between ion channel genes and intracranial aneurysmal subarachnoid hemorrhage.

Abstract excerpt

Aneurysmal subarachnoid hemorrhage (aSAH) is a complex condition associated with high disability and mortality rates, leading to poor clinical outcomes. Previous observational studies have suggested a link between ion channel genes and aSAH, but the causal relationship remains uncertain. This study utilized Mendelian randomization (MR) to explore the causal association between ion channel genes and aSAH,...

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