Article
Compression enhances invasive phenotype and matrix degradation of breast Cancer cells via Piezo1 activation.
BMC molecular and cell biology - 3 Jan 2022
Luo Mingzhi, Cai Grace, Ho Kenneth K Y, Wen Kang, Tong Zhaowen, Deng Linhong, Liu Allen P
Abstract excerpt
BACKGROUND: Uncontrolled growth in solid breast cancer generates mechanical compression that may drive the cancer cells into a more invasive phenotype, but little is known about how such compression affects the key events and corresponding regulatory mechanisms associated with invasion of breast cancer cells including cellular behaviors and matrix degradation. RESULTS: Here we show that compression enhanced...
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