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Article

A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα.

Nature neuroscience - 28 Aug 2011

Valnegri Pamela, Khelfaoui Malik, Dorseuil Olivier, Bassani Silvia, Lagneaux Celine, Gianfelice Antonella, Benfante Roberta, Chelly Jamel, Billuart Pierre, Sala Carlo, Passafaro Maria

Abstract excerpt

Oligophrenin-1 regulates dendritic spine morphology in the brain. Mutations in the oligophrenin-1 gene (OPHN1) cause intellectual disability. We discovered a previously unknown partner of oligophrenin-1, Rev-erbα, a nuclear receptor that represses the transcription of circadian oscillators. We found that oligophrenin-1 interacts with Rev-erbα in the mouse brain, causing it to locate to dendrites, reducing its...

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PMID: 21874017
DOI: 10.1038/nn.2911

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OPHN1

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