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Identification of naturally occurring drug-resistant mutations of SARS-CoV-2 papain-like protease

15 May 2025

Abstract excerpt

The SARS-CoV-2 papain-like protease (PLpro) is a cysteine protease that cleaves viral polyproteins and antagonizes the host immune response during viral replication. Jun12682 and PF-07957472 are the first-in-class PLpro inhibitors showing potent in vivo antiviral efficacy in mouse models. In this study, we characterize naturally occurring mutations at residues located at the drug-binding site of Jun12682. The...

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PMID: 40379662
DOI: 10.1038/s41467-025-59922-9

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