Article

Discovery of SARS-CoV-2 papain-like protease inhibitors through machine learning and molecular simulation approaches

2025-04-08

Abstract excerpt

<title>Abstract</title> <p>The papain-like protease (PLpro), a cysteine protease found in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), plays a crucial role in viral replication by cleaving the viral polyproteins and interfering with the host's innate immune response through deubiquitination and deISGylation activities. Consequently, targeting PLpro has emerged as an appealing therapeutic strategy...

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Literature Corpus work: e7dc1228-da80-575b-85e0-d592fe8a8008
DOI: 10.21203/rs.3.rs-6358467/v1

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