Autophagy and Human Neurodegenerative Diseases—A Fly’s Perspective

Abstract excerpt

Neurodegenerative diseases in humans are frequently associated with prominent accumulation of toxic protein inclusions and defective organelles. Autophagy is a process of bulk lysosomal degradation that eliminates these harmful substances and maintains the subcellular environmental quality. In support of autophagy's importance in neuronal homeostasis, several genetic mutations that interfere with autophagic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Lysosomal Storage Disorders Research
• Share to Parkinson's Disease Mechanisms and Treatments