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Article

Genetic and in vivo determinants of glucocorticoid sensitivity in relation to clinical outcome of childhood nephrotic syndrome.

Kidney international - 1 Jun 2014

Teeninga Nynke, Kist-van Holthe Joana E, van den Akker Erica L T, Kersten Marie C, Boersma Eric, Krabbe Hans G, Knoers Nine V A M, van der Heijden Albert J, Koper Jan W, Nauta Jeroen

Abstract excerpt

Following initial glucocorticoid treatment, the clinical course in children with nephrotic syndrome is highly variable. Intrinsic sensitivity to glucocorticoids might be a determinant of this variability. Functional polymorphisms of the glucocorticoid receptor gene NR3C1 have been associated with either relatively impaired (GR-9β) or increased (BclI) glucocorticoid sensitivity. Here, in a prospective,...

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PMID: 24429396
DOI: 10.1038/ki.2013.531

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