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Article

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.

Blood - 1 Oct 2008

Brenchley Jason M, Paiardini Mirko, Knox Kenneth S, Asher Ava I, Cervasi Barbara, Asher Tedi E, Scheinberg Phillip, Price David A, Hage Chadi A, Kholi Lisa M, Khoruts Alexander, Frank Ian, Else James, Schacker Timothy, Silvestri Guido, Douek Daniel C

Abstract excerpt

Acute HIV infection is characterized by massive loss of CD4 T cells from the gastrointestinal (GI) tract. Th17 cells are critical in the defense against microbes, particularly at mucosal surfaces. Here we analyzed Th17 cells in the blood, GI tract, and broncheoalveolar lavage of HIV-infected and uninfected humans, and SIV-infected and uninfected sooty mangabeys. We found that (1) human Th17 cells are specific for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18664624
DOI: 10.1182/blood-2008-05-159301
PMCID: PMC2556618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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