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A comprehensive genetic study of classic Hodgkin lymphoma using circulating tumor DNA

13 May 2025

Abstract excerpt

ABSTRACT: This study analyzed the genetics of classic Hodgkin lymphoma (cHL) by using circulating tumor DNA (ctDNA). Two genetic subtypes were identified, differing in genetic instability mechanisms: one subtype (64% of cases) showed a higher mutation load and a higher fraction of mutations associated with activation-induced cytidine deaminase and microsatellite instability signatures, whereas the other subtype...

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PMID: 40359477
DOI: 10.1182/blood.2024027355

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