Article
Mutation profiling of circulating tumor DNA identifies distinct mutation patterns in non-Hodgkin lymphoma.
European journal of haematology - 1 Apr 2022
Fu Haiying, Shen Jianzhen, Zhou Huarong, Zhang Feng, Li Hongping, Ma Zhiming, Huang Wanling, Chen Lushan, Chen Yi, Liu Tingbo
Abstract excerpt
OBJECTIVE: Circulating tumor DNA (ctDNA) is emerging as a versatile biomarker for noninvasive genotyping and response monitoring in specific B-cell lymphomas; however, few studies have been conducted to explore ctDNA-based mutation profiling across non-Hodgkin lymphomas (NHLs) and genomic changes after initiation of chemotherapy. METHODS: A targeted sequencing of 362 genes was performed to detect the mutation...
Topics
- Carrier Proteins
- Circulating Tumor DNA
- Humans
- Lymphoma, Large B-Cell, Diffuse
- Lymphoma, Non-Hodgkin
- Mutation
- Nerve Tissue Proteins
- Prognosis