Article

Genetic and chemotherapeutic causes of germline hypermutation

2021-06-01

Abstract excerpt

<h4>Summary</h4> Mutation in the germline is the source of all evolutionary genetic variation and a cause of genetic disease. Previous studies have shown parental age to be the primary determinant of the number of new germline mutations seen in an individual’s genome. Here we analysed the genome-wide sequences of 21,879 families with rare genetic diseases and identified 12 hypermutated individuals with between tw...

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Literature Corpus work: 4cf814aa-d858-5d06-842c-593be7665513
DOI: 10.1101/2021.06.01.446180

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