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The Genetic Footprint of Tobacco Smoking: Unraveling the Mutational Signatures in Head and Neck Cancer.

Cancer research - 1 Aug 2025

Mimura Kaito, Yoshida Kenichi

Abstract excerpt

Tobacco smoking and alcohol consumption are among the most significant, yet preventable, behavioral risk factors for cancer. In a recent article in Nature Genetics, Torrens and colleagues performed whole-genome sequencing of 265 head and neck cancer samples collected from 8 countries across Europe and South America. They investigated the mechanisms underlying head and neck cancer development using mutational...

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PMID: 40354630
DOI: 10.1158/0008-5472.CAN-25-1990

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