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Article

Does smoking alter the mutation profile of human papillomavirus-driven head and neck cancers?

European journal of cancer (Oxford, England : 1990) - 1 May 2018

Mirghani Haitham, Lacroix Ludovic, Rossoni Caroline, Sun Roger, Aupérin Anne, Casiraghi Odile, Villepelet Aude, Lacave Roger, Faucher Gladwys, Marty Virginie, Ferté Charles, Soria Jean Charles, Even Caroline

Abstract excerpt

BACKGROUND: Human papillomavirus (HPV)-driven oropharyngeal cancer (OPC) patients are characterised by a better prognosis than their HPV-negative counterparts. However, this significant survival advantage is not homogeneous and among HPV-positive patients those with a smoking history have a significantly increased risk of oncologic failure. The reason why tobacco consumption impacts negatively the prognosis is...

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Identifiers

PMID: 29533868
DOI: 10.1016/j.ejca.2018.02.013

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FGFR3
NOTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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