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Article

Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma.

PloS one - 1 Jan 2013

Urashima Mitsuyoshi, Hama Takanori, Suda Toshihito, Suzuki Yutaka, Ikegami Masahiro, Sakanashi Chikako, Akutsu Taisuke, Amagaya Suguru, Horiuchi Kazuhumi, Imai Yu, Mezawa Hidetoshi, Noya Miki, Nakashima Akio, Mafune Aki, Kato Takakuni, Kojima Hiromi

Abstract excerpt

BACKGROUND: Tobacco and alcohol consumption are risk factors for head and neck squamous cell carcinoma (HNSCC). Recently, whole-exome sequencing clarified that smoking increased TP53 and other mutations in HNSCC; however, the effects of alcohol consumption on these genetic alterations remain unknown. We explored the association between alcohol consumption and somatic copy-number alterations (SCNAs) across the...

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Topics

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Share to Alcohol Drinking
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human

Share to DNA Copy Number Variations

Share to Head and Neck Neoplasms

Share to Papillomavirus Infections

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Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 24278325
DOI: 10.1371/journal.pone.0080828
PMCID: PMC3835411

Genes

CCND1
CCNL1
CSMD1
CTTN
ERBB2
FADD
FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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