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Article

Genetic and Molecular Differences in Head and Neck Cancer Based on Smoking History.

JAMA otolaryngology-- head & neck surgery - 1 Apr 2025

Jiang Rong, Gao May Z, Chen Meng, Weatherspoon Darien J, Watts Tammara L, Osazuwa-Peters Nosayaba

Abstract excerpt

Importance: Up to 80% of survivors of head and neck squamous cell carcinoma (HNSCC) currently or previously smoked. Thus, tobacco use is a major modifiable risk factor for HNSCC, even in the era of human papillomavirus (HPV)-associated disease. However, how smoking underlies chromosomal and epigenetic changes that are associated with HNSCC outcomes remains unclear. Objective: To characterize genetic and molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40048195
DOI: 10.1001/jamaoto.2024.5409
PMCID: PMC11886874

Genes

FADD
CCND1
CTTN
FGF19
LTO1
PPFIA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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