Article
The Proteomic Landscape of CTNNB1 Mutated Low-Grade Early-Stage Endometrial Carcinomas.
Cells - 27 Oct 2025
Lopez-Janeiro Alvaro, Brizzi Emilia, Ruz-Caracuel Ignacio, Alexandru Raluca, de Andrea Carlos, Berjón Alberto, Yebenes Laura, Mendiola Marta, Heredia-Soto Victoria, Montero-Calle Ana, Barderas Rodrigo, de Los Rios Vivian, Redondo Andrés, Pelaez-Garcia Alberto, Hardisson David
Abstract excerpt
Endometrial carcinoma is the most frequent gynecologic malignancy in western countries. In recent years, mutations in CTNNB1 have been associated with worse prognosis in low-risk carcinomas. However, there is a lack of understanding of the proteomic implications of CTNNB1 mutations in this type of tumor. In this study, we performed shotgun proteomics using Formalin-Fixed Paraffin-Embedded (FFPE) tissue samples of...
Read the complete abstract on PubMedTopics
- Humans
- Female
- beta Catenin
- Endometrial Neoplasms
- Mutation