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Article

C9orf72 ALS mutation carriers show extensive cortical and subcortical damage compared to matched wild-type ALS patients.

NeuroImage. Clinical - 1 Jan 2023

Nigri Anna, Umberto Manera, Stanziano Mario, Ferraro Stefania, Fedeli Davide, Medina Carrion Jean Paul, Palermo Sara, Lequio Laura, Denegri Federica, Agosta Federica, Filippi Massimo, Valentini Maria Consuelo, Canosa Antonio, Calvo Andrea, Chiò Adriano, Bruzzone Maria Grazia, Moglia Cristina

Abstract excerpt

OBJECTIVE: C9orf72 mutation carriers with different neurological phenotypes show cortical and subcortical atrophy in multiple different brain regions, even in pre-symptomatic phases. Despite there is a substantial amount of knowledge, small sample sizes, clinical heterogeneity, as well as different choices of image analysis may hide anatomical abnormalities that are unique to amyotrophic lateral sclerosis (ALS)...

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Identifiers

PMID: 37068310
DOI: 10.1016/j.nicl.2023.103400
PMCID: PMC10130353

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