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Article

Molecular Subtype and Mutational Profile of Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Mar 2026

Leino Annamari, Nostolahti Anton, Ahtikoski Anne, Huvila Jutta

Abstract excerpt

Endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia (EAH/EIN) is the acknowledged precursor of most endometrial carcinomas. Our aim was to assess the molecular alterations and the 4 specific molecular subtypes in EAH/EIN diagnosed on endometrial biopsy. Forty EAH/EIN biopsies were stained for estrogen receptor (ER), mismatch repair (MMR) proteins (PMS2 and MSH6), and p53 and were subjected to...

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Source

Identifiers

PMID: 40341112
DOI: 10.1097/PGP.0000000000001113

Genes

POLE
CTNNB1
MSH6
PIK3CA
PMS2
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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