Molecular Characterization of Endometrial Cancer Using a Laboratory-Developed Multi-Gene NGS Panel.

doi:10.3390/ijms27167384

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Article

Molecular Characterization of Endometrial Cancer Using a Laboratory-Developed Multi-Gene NGS Panel.

International journal of molecular sciences - 18 Aug 2026

Maloberti Thais, Altimari Annalisa, Gruppioni Elisa, Poppi Laura, Sanza Viviana, Costantino Alessia, Coluccelli Sara, Calafato Giulia, Di Paola Floriana Jessica, Ravaioli Caterina, Corradini Angelo Gianluca, Grillini Marco, Perrone Anna Myriam, De Iaco Pierandrea, Rubino Daniela, Zamagni Claudio, Tallini Giovanni, De Leo Antonio, de Biase Dario

Abstract excerpt

Endometrial carcinoma is a biologically and clinically heterogeneous neoplasm, for which molecular classification now plays a central role in determining prognosis and guiding treatment. The aim of this study was to develop and apply an in-house multi-gene NGS panel to expand the molecular characterization of endometrial tumors beyond the markers required for surrogate classification. Seventy primary endometrial...

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