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Article

Molecular classification of endometrial carcinoma: clinical utility of an NGS panel with targeted detection of 116 cancer-related genes.

Pathology oncology research : POR - 1 Jan 2026

Chen Lingfeng, You Zhijie, Yu Xunbin, Wu Yijuan, Chen Xin, Lin Jie

Abstract excerpt

Background: This study aimed to evaluate the efficacy of a single-test, targeted DNA next-generation sequencing (NGS) panel in classifying endometrial carcinoma (EC) into molecular subtypes and to compare its performance with that of the established Sanger sequencing + immunohistochemistry (Sanger + IHC) molecular classification. Methods: Targeted DNA NGS was performed on 131 samples using the clinically...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42582151
DOI: 10.3389/pore.2026.1612465
PMCID: PMC13457160

Genes

POLE
TP53
ARID1A
PIK3CA
PTEN

Provenance

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