Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Molecular classification of endometrial carcinoma: clinical utility of an NGS panel with targeted detection of 116 cancer-related genes.

Pathology oncology research : POR - 1 Jan 2026

Chen Lingfeng, You Zhijie, Yu Xunbin, Wu Yijuan, Chen Xin, Lin Jie

Abstract excerpt

Background: This study aimed to evaluate the efficacy of a single-test, targeted DNA next-generation sequencing (NGS) panel in classifying endometrial carcinoma (EC) into molecular subtypes and to compare its performance with that of the established Sanger sequencing + immunohistochemistry (Sanger + IHC) molecular classification. Methods: Targeted DNA NGS was performed on 131 samples using the clinically...

Topics

Humans
Female
Endometrial Neoplasms
High-Throughput Nucleotide Sequencing
Biomarkers, Tumor
Mutation
Middle Aged
Microsatellite Instability
Aged
Immunohistochemistry
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Adult

Aged, 80 and over

Source

Open in PubMed Open full text

Identifiers

PMID: 42582151
DOI: 10.3389/pore.2026.1612465
PMCID: PMC13457160

Genes

POLE
TP53
ARID1A
PIK3CA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular classification of endometrial carcinoma: clinical utility of an NGS panel with targeted detection of 116 cancer-related genes.PMID 42582151Read ↗

Identification of molecular subtypes for endometrial carcinoma using a 46-gene next-generation sequencing panel: a retrospective study on a consecutive cohort.Semantic proximity Read ↗

Advantages of next-generation sequencing (NGS) in the molecular classifi cation of endometrial carcinomas - our experience with 270 cases.Semantic proximity Read ↗

Integration of clinical sequencing and immunohistochemistry for the molecular classification of endometrial carcinoma.Semantic proximity Read ↗

Clinical Application of Next-Generation Sequencing for Molecular Classification in the Management of Endometrial Cancer: An Observational Cohort StudySemantic proximity Read ↗

Harmonized molecular classification; assessment of a single-test ProMisE NGS tool.Semantic proximity Read ↗

Molecular testing for endometrial cancer: An SGO clinical practice statement.Semantic proximity Read ↗

Prospective Clinical Prognostication of Endometrial Carcinomas Based on Next-Generation Sequencing and Immunohistochemistry-Real-World Implementation and Results at a Tertiary Care Center.Semantic proximity Read ↗

One-stop molecular classification of endometrial carcinoma using comprehensive next-generation sequencing.Semantic proximity Read ↗

Validation of a one-step genomics-based molecular classifier for endometrial carcinoma in a large Chinese population.Semantic proximity Read ↗

Molecular subtype diagnosis of endometrial carcinoma: comparison of the next-generation sequencing panel and Proactive Molecular Risk Classifier for Endometrial Cancer classifier.Semantic proximity Read ↗

A fully next-generation sequencing-based method of classifying molecular sub-types of endometrial cancer retains prognostic value and expands biomarker targets.Semantic proximity Read ↗

The emerging role of molecular pathology in directing the systemic treatment of endometrial cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.