Article
Advantages of next-generation sequencing (NGS) in the molecular classifi cation of endometrial carcinomas - our experience with 270 cases.
Ceska gynekologie - 1 Jan 2024
Michalová Květoslava, Presl Jiří, Straková-Peteříková Andrea, Ondič Ondrej, Vaneček Tomáš, Hejhalová Nikola, Holub Petr, Slavík Petr, Hluchý Adam, Gettse Polina, Daum Ondřej, Švajdler Marián, Michal Michal
Abstract excerpt
OBJECTIVE: Molecular classification of endometrial carcinomas (EC) divides these neoplasms into four distinct subgroups defined by a molecular background. Given its proven clinical significance, genetic examination is becoming an integral component of the diagnostic procedure. Recommended diagnostic algorithms comprise molecular genetic testing of the POLE gene, whereas the remaining parameters are examined...
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