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Article

Effect of isolated keratin 3 knockdown on gene expression of primary limbal epithelial cells without and with inflammatory stimuli

5 May 2025

Abstract excerpt

PURPOSE: Studies have shown that keratin 3 (KRT3) expression is reduced in paired box 6 (PAX6) haploinsufficient primary limbal epithelial cells (LECs). The downregulation of KRT3 expression due to PAX6 haploinsufficiency is likely a critical factor in the development and progression of aniridia associated keratopathy (AAK). In addition, the ocular surface of congenital aniridia patients exhibits an inflammatory...

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PMID: 40334825
DOI: 10.1016/j.aanat.2025.152670

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