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<p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;"><span lang="EN-GB" style="mso-bidi-font-size: 18.0pt; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold;">FOXC1 Regulates Transcriptional Control of Cytokine Signaling, Selective Inflammatory Pathways and Retinoid Metabolism to Maintain Epithelial Homeostasis, Cell Fate and Integrity in Limbal Epithelial Cells, <span style="mso-bidi-font-style: italic;">In Vitro

2026-01-13

Abstract excerpt

This study aimed to evaluate FOXC1-mediated regulatory mechanisms on gene and protein expression profiles in primary human limbal epithelial cells (pLECs), via siRNA knockdown; under basal and lipopolysaccharide (LPS) and interleukin-1β (IL-1β) induced inflammatory conditions. Gene expression was analysed for markers related to inflammation (CCL2, IL-6, IL-8, TNF-α, TGF-β), epithelial differentiation (KRT3, KRT12,...

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Literature Corpus work
0b3f68f0-2137-574b-a9f9-3dbbb5243b87
DOI
10.20944/preprints202601.0704.v1
Open publication

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<p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;"><span lang="EN-GB" style="mso-bidi-font-size: 18.0pt; mso-ansi-language: EN-GB; mso-bidi-font-weight: bold;">FOXC1 Regulates Transcriptional Control of Cytokine Signaling, Selective Inflammatory Pathways and Retinoid Metabolism to Maintain Epithelial Homeostasis, Cell Fate and Integrity in Limbal Epithelial Cells, <span style="mso-bidi-font-style: italic;">In VitroDOI 10.20944/preprints202601.0704.v1
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