Article

Cell signaling pathways in human mutant PAX6 corneal cells: an in vitro model for aniridia-related keratopathy

2021-03-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>PURPOSE</h4> To establish an in vitro model of aniridia-related keratopathy (ARK) using CRISPR/Cas9 engineered human keratocytes with mutations in the PAX6 gene, and to study the Notch Homolog 1, Translocation-Associated (Notch1), sonic hedgehog (SHH), mammalian target of rapamycin (mTOR), and Wnt/β-catenin signaling pathways in the PAX6 mutant keratocytes. <h4>METHODS</h4> Primary human...

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Literature Corpus work: c5c8040e-3004-50d9-a2a0-93cc42ab40c1
DOI: 10.1101/2021.03.19.436143

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