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Article

Effects of miR-204-5p modulation on PAX6 regulation and corneal inflammation

2 Nov 2024

Abstract excerpt

Abstract Congenital aniridia is a rare eye disease characterized by loss of PAX6 protein leading to aniridia-associated keratopathy that significantly reduces vision. The miR-204-5p is a possible regulator of PAX6 function and here we evaluate its effect in multiple in vitro and in vivo models. In vitro, miR-204-5p overexpression suppressed vascular factor ANGPT1 in human limbal stem cells (T-LSC) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39488562
DOI: 10.1038/s41598-024-76654-w

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