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Elucidating Genetic and Immunological Pathways Mediated by Sodium-Glucose Transporter 2 Inhibitors in Reducing Gout Risk: A Two-Step Mendelian Randomization Study.

Assay and drug development technologies - 1 Jan 2025

Zeng Huiqiong, Cai Zebo, Lai Junda, Chen Zhijun, Liu Wei, Zhang Ye

Abstract excerpt

While sodium-glucose transporter 2 inhibitors (SGLT2i) demonstrate urate-lowering effects, their causal role in Gout prevention remains controversial. This study employs advanced Mendelian randomization (MR) techniques to dissect immune-mediated mechanisms underlying this relationship. Using bidirectional two-sample MR and mediation analysis, we analyzed genetic instrument variables for SGLT2i (10...

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PMID: 40333450
DOI: 10.1089/adt.2024.137

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CD86

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