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Bidirectional two-sample Mendelian randomization analysis unveils causal association between inflammatory cytokines and the risk of diabetic nephropathy.

Scientific reports - 25 Oct 2024

Song Siyuan, Yan Qianhua, Yu Jiangyi

Abstract excerpt

OBJECTIVE: Previous observational studies have indicated associations between various inflammatory cytokines and diabetic nephropathy (DN) caused by type 2 diabetes mellitus (T2DM). However, the causality remains unclear. We aimed to further evaluate the causal association between 91 inflammatory cytokines and DN using bidirectional two-sample Mendelian randomization (MR) analysis. METHOD: Summary statistics for...

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Cytokines
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Identifiers

PMID: 39455620
DOI: 10.1038/s41598-024-73800-2
PMCID: PMC11511841

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