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Unraveling the gut–immune–kidney axis in kidney stone disease: a two-step Mendelian randomization investigation

20 Aug 2025

Abstract excerpt

The gut microbiota (GM) is increasingly acknowledged for its regulatory role in host immune responses and its influence on various systemic diseases. Nevertheless, whether GM modulates kidney stone disease (KSD) through immune-related mechanisms remains uncertain. To investigate these associations, we conducted Mendelian randomization (MR) analyses in two sequential steps, employing summary-level data sourced...

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PMID: 40833634
DOI: 10.1007/s00240-025-01830-0

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