Article
Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Abou-Fadel Johnathan, Zhang Jun
Abstract excerpt
The use of vertebrate models allows researchers to investigate mechanisms of CCM pathogenesis in vivo, to investigate discrepancies between observations seen in the lab with in vitro experiments and how they translate into animal models; these in vivo models are more relevant in terms of CCM pathogenesis seen in humans than the in vitro counterparts. The use of CCM-deficient Zebrafish model offers advantages...
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